acetyl chloride การใช้

• The third reaction involved intermediate XVII undergoing acylation using acetyl chloride.
• Can I ask why the acetyl chloride is so necessary?
• It can be formed by reacting chlorine with acetyl chloride or acetaldehyde in the presence of activated charcoal.
• "' Acetyl chloride "', CH 3 COCl is an acid chloride derived from acetic acid.
• The OH group is the main site of reaction, as illustrated by the conversion of acetic acid to acetyl chloride.
• A few halocarbons, including acid halides like acetyl chloride, are highly reactive; these are rarely found outside chemical processing.
• Benzylamine reacts with acetyl chloride to form " N "-benzylacetamide, an exemplar of the Schotten Baumann reaction first described in the 1880s.
• A less corrosive compound of salicylic acid, acetylsalicylic acid, produced by reacting sodium salicylate with acetyl chloride, was developed from 1897 by Felix Hoffmann and Arthur Eichengr黱.
• Aspirin ( acetylsalicylic acid or ASA ) can be prepared by the esterification of the phenolic hydroxyl group of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride.
• In the course of his work on the synthesis and properties of various acid anhydrides, he mixed acetyl chloride with a sodium salt of salicylic acid ( sodium salicylate ).
• Chlorination at with aluminium chloride and acetyl chloride yields equal amounts of 1-and 4-chlorodiamantane, whereas use of chlorosulfonic acid yields mainly the 1-chloro isomer.
• In 1853, chemist Charles Fr閐閞ic Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis.
• It is produced in the same fashion as other esters of morphine-- treating morphine with an acid anhydride ( or some acids or other relatives of acids like acetyl chloride ) to get a mono-, di-, tri-, or tetra-ester.
• In 1853, chemist Charles Fr閐閞ic Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; The word " Aspirin " was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rights to the trademark were lost or sold in many countries.
• It undergoes Friedel-Crafts acylation with acetyl chloride and aluminium chloride to give the acyl derivative "'2 "', with formaldehyde and hydrochloric acid to the chloromethyl derivative "'3 "', in a Vilsmeier-Haack reaction with N-methylformanilide and phosphorus oxychloride to the formyl "'4 "', and in a Mannich reaction to amine derivative "'5 " '.
• Both were developed in Austria in the 1920s along with other derivatives of the strong dihydromorphinones and these drugs are generated by reacting oxymorphone with either acetic anhydride or acetyl chloride at various temperatures in the 80-160 癈 for several hours; 3, 6, 14-triacetyloxymorphone may be more easily made when a catalylst is used but elevated pressure or reaction " in vacuo " or under a nitrogen or noble gas atmosphere is not required.